WHAT’S HAPPENING?

Margarita Correa
30/Jan/2020

Micronized Purified Flavonoid Fraction (Diosmin) is a natural compound with a wide range of biological activity, e.g., it improves lymphatic drainage, supports microcirculation, and increases venous tone, and venous elasticity, hence, it is applied in the pharmacotherapy of chronic venous disorders (CVD).

Diosmin administration modulates pro-inflammatory as well as pro- and anti-angiogenic mechanisms in CVD pathology.

The main goal of micronized purified flavonoid fraction (MPFF) of diosmin and hesperidin is to eliminate the symptoms of CVD (venous pain, fatigue, etc). MPFF of diosmin and hesperidin has a good effect on the treatment of venous edema and venous ulcer too. Many papers prove its effectiveness in the experiment and the microcirculation. The other indications for MPFF of diosmin hesperidin are a hemorrhoidal disease and the accessory treatment of lymphedema.

As a pharmacological vasoactive agent, diosmin can protect CVD patients against edema progression by inhibition of inflammatory pathways, simultaneously influencing pro-angiogenic/anti-angiogenic balanced by an increase of anti-angiogenic factor and reducing the level of pro-angiogenic factors.

The general level of evidence supports the recommendation that the use of medical therapy with Micronized Purified Flavonoid Fraction (MPFF) has beneficial outcomes without serious adverse events.

The Micronized Purified Flavonoid Fraction (MPFF) it is derived from the rinds of oranges and is categorized as a medical food and not as a drug, and maybe a particularly attractive therapy for many chronic venous disease patients because of its favorable safety profile.

DioVasc™ contains well-researched, citrus-based flavonoids in a unique micronized form for enhanced absorption and bioavailability. Research suggests that these compounds support healthy veins, capillaries, and blood flow; promote healthy lymphatic drainage; and enhance antioxidant activity; and support healthy eicosanoid metabolism. More recent research suggests that the components in DioVasc also support blood glucose metabolism.*

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References:

1.Batchvarov I.V., Batselova M.G., Damyanov I.I. One-year diosmin therapy (600 mg) in patients with chronic venous insufficiency—results and analysis. J. Biomed. Clin. Res. 2010;3:51–54

2.Shishlo VK, et al. Mechanisms of antioedemic effect of bioflavonoids in the experiment. Angiol Sosud Khir. 2013.

3.Bush R, et al. Recommendations for the medical management of chronic venous disease: The role of Micronized Purified Flavanoid Fraction (MPFF). Phlebology. 2017.

4.Feldo M, etal. Effect of Diosmin Administration in Patients with Chronic Venous Disorders on Selected Factors Affecting Angiogenesis. Molecules. 2019.


Margarita Correa
19/Oct/2019

Now you can watch the video of Margarita Correa MD presenting along side with Karen Herbst, MD, PhD, John Bartholomew, MD and Karen Beltran on Saturday, April 9 2016 Panel Discussion FDRS 2016 informing on Diagnosis and Treatment of Lipedema.

The FDRS 2016 Conference: Living with Lipedema and Dealing with Dercum’s was on April 8-10, 2016 at the Marriott St. Louis Airport hotel in St. Louis, MO. Keynote speaker is world renowned Fat Disorder expert, Karen L. Herbst, MD, PhD. Topics to include surgical and non-surgical treatment options in managing both Lipedema and Dercum’s Disease.


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Margarita Correa
30/Jan/2018

ICG lymphography is a study of the superficial lymphatics, not a treatment, helps define lymphatic dysfunction and delineate individualized lymphedema treatment. This study also helps visualize lymphedema in the asymptomatic limb. Superficial lymphatics accounts for 70% of the lymphatic system.


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Margarita Correa
17/Sep/2017

Health coaches provide guidance and management in the major components of health, including diet, physical activity and wellness. They help people identify their ideal health goals, define a customized plan and guide them in putting the plan into action.


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